A darwinian process: the molecular evolution of enzymes
Keywords:
darwinian process, enzyme promiscuity, molecular evolution, information, emergence, biotechnology, creation, intelligent designAbstract
New concepts as ambiguity, promiscuity and plasticity have allowed getting a deeper insight in the mechanism of the Darwinian process implied in the molecular evolution of enzymes. Directed evolution in the laboratory collapses the time scale for evolution from millions of years to months or even weeks due that the key processes: mutations, recombination, screening or selection are carefully controlled by the experimenter. In order to get a more meaningful vision a more enlarged scientific background is presented. The philosophical reflections focus on the increasing information in the evolution process, which goes beyond the dualism matter-spirit, and on the successive emergences. Finally some ethical and theological reflections are proposed.Downloads
References
R. WOLFENDENDO and M. J. SNIDER, Acc. Chem. Res. 34 (2001) 938-945.
C. CHENG, B. QIAN, R. SAMUDRALA and D. BAKER, Nucleic Acids. Res. 33 (2005) 5861-5867.
M. ROCA, S. MARTÍ, J. ANDRÉS, V. MOLINER, E. SILLA, I. TUÑÓN and J. BERTRÁN, Chem. Soc. Rev. 33 (2004) 98-107.
P. J. O’BRIEN and D. HERSCHLAG, Chem. & Biol., 1999, R91-R105.
O. KHERSONSKY, C. ROODVELDT and D. S. TAWFIK, Curr. Opinion Chem. Biol. 10 (2006) 498-508.
M. D. TOSCANO, K. J. WOYCECHOWSKY and D. HILVERT, Angew. Chem. Int. Ed. 46 (2007) 3212-3236.
J. D. MARÉCHAL and M. J. SUTCLIFFE, Curr. Topics Med. Chem. 6 (2006) 1619-1626.
M. W. CROWDER, J. SPENCER and A. J. VILA, Acc. Chem. Res. 39 (2005) 721-728.
L. AFRIAT, C. ROODVELDT, G. MANCO and D. S. TAWFIK, Biochemistry 45 (2006) 13677-13685.
I. CATRINA, P. J. O’BRIEN, J. PURCELL, I. NIKOLIC-HUGHES, J. G. ZALATAN, A. C. HENGGE and D. HERSCHLAG, J. Am. Chem. Soc. 129 (2007) 5760-5765.
J. G. ZALATAN, T. D. FENN, A. T. BRUNGER and D. HERSCHLAG, Biochemistry 45 (2006) 9788-9803.
J. E. VICK and J. A. GERLT, Biochemistry 46 (2007) 14589-14597.
F. H. ARNOLD, Acc. Chem. Res. 31 (1998) 125-131.
M. N. CARBONE and F. H. ARNOLD, Curr. Opinion Struct. Biol. 17 (2007) 454-459.
K. L. MORLEY and R. J. KAZLAUSKAS, Trends in Biotechnology 23 (2005) 231-237.
S. MARTI, J. ANDRÉS, V. MOLINER, E. SILLA, I. TUÑÓN and J. BERTRÁN, Angew. Chem. Int. Ed. 46 (2007) 286-290.
S. MARTI, J. ANDRÉS, V. MOLINER, E. SILLA, I. TUÑÓN and J. BERTRÁN, J. Am. Chem. Soc. 130 (2008) 2894-2895.
E. KEINAN (ed.), Catalytic Antibodies, Wiley-VCH Verlag, Weinheim, 2005.
M. A. DWYER, L. L. LOOGER and H. W. HELLINGA, Science 304 (2004) 1967-1971.
T. DOBZHANSKY, Am. Biol. Teach. 35 (1973) 125-129.
C. DARWIN, On the origin of species by means of natural selection, John Murray, London, 1859.
S. D. COPLEY, Curr. Opinion Chem. Biol. 7 (2003) 265-272.
S. A. KAUFFMAN, The origins of order: self-organization and selection in evolution, Oxford Univ. Press, Oxford, 1993.
S. A. KAUFFMAN, At home in the universe, Oxford Univ. Press, Oxford, 1995.
T. FEHER, B. PAPP, C. PAL and G. POSFAI, Chem. Rev. 107 (2007) 3498-3513.
A. POHORILLE and D. DEAMER, Trends in Biotechnology 20 (2002) 123-128.
E. E. SZATHMARY, M. SANTOS and CH. FERNANDO, Top Curr. Chem. 259 (2005) 167-211.
J. KIRBY, D. W. ROMANINI, E. M. PARADISE and J. D. KEASLING, FEBS Journal 275 (2008) 1852-1859.
P. TEILHARD, Hymne de l’universe, Éditions du Seuil, Paris, 1961.
P. HEFNER, in Cosmos as creation: Theology and Science in consonance, ed. Ted Peters, Nashville, Abingdon, 1989, p. 227.
F. S. COLLINS, ¿Cómo habla Dios?, Ediciones Temas de Hoy, S.A., Madrid, 2007.
F. J. AYALA, Darwin y el diseño inteligente, Alianza Editorial, Madrid, 2007.
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