Francisco J. Ayala: Scientist, Humanist and Friend
DOI:
https://doi.org/10.14422/ryf.vol288.i1464.y2024.008Keywords:
neutral evolution, phylogeny, molecular clock, science and religion, biological ethicsAbstract
Francisco J. Ayala was a dominant figure in evolutionary biology from the mid 20th through the first two decades of the 21st century. The purpose of this article is to try to place his work into the larger context of evolutionary biology and to briefly consider his important contributions to the philosophy of biology, including reconciling biological evolution and religion and his writings on the evolution of ethics. Another amore personal purpose is to recount his influence on me and on a whole generation of evolutionary geneticists. To achieve these twin purposes, I place his work into the larger historical context with a focus on his early work providing rigorous empirical tests of the hypothesis of neutral gene evolution in 1970s. I try to give some flavor for the human being behind an incredible body of work and to explicate some of the forces that may have influenced his development.
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References
Allison, A. C. (1955). Aspects of polymorphism in man, Cold Spring Harbor Symp. Quant. Biol., 20, 239-255.
Ayala, F. J. (1969). Experimental invalidation of the principle of competitive exclusion, Nature, 224, 1076-1079.
Ayala, F. J. (1989). On Being A Scientist (NAS Committee on the Conduct of Science, F.J. Ayala, Chairman.), Proc. Natl. Acad. Sci., 86, 9053-9074.
Ayala, F. J. (1997). Vagaries of the molecular clock, Proc. Natl. Acad. Sci. USA, 94, 7776-7783.
Ayala, F. J. (1999). Molecular clock mirages, BioEssays, 21, 71-75.
Ayala, F. J. (1999). Science and Creationism. A View from the National Academy of Sciences. National Academy Press.
Ayala, F. J. (2007). Darwin’s Gift to Science and Religion. Joseph Henry Press.
Ayala, F. J. (2013). On the Origins of Modern Science: Copernicus and Darwin, In: S.L. Sorgner and B.-R. Jovanovic (eds.). Evolution and the Future. Anthropology, Ethics, Religion (pp. 101-113). Peter Lang.
Ayala, F. J. (2017a). The Evolution of Ethics, Center For Humans & Nature, https://www.humansandnature.org/the-evolution-of-ethics.
Ayala, F. J. (2017b). Adaptive Significance of Ethics and Aesthetics, In: M. Tibayrenc and F.J. Ayala, eds., On Human Nature. Biology, Psychology, Ethics, Politics, and Religion (pp. 601-623). Academic Press.
Ayala, F .J. (2017c). Human Evolution and Progress, In: M. Tibayrenc and F.J. Ayala (eds.). On Human Nature. Biology, Psychology, Ethics, Politics, and Religion (pp. 565-577). Academic Press.
Ayala, F.J., Mourão, C.A., Pérez-Salas, S., Richmond, R. & Dobzhansky, Th. (1970). Enzyme variability in the Drosophila willistoni group. I. Genetic differentiation among sibling species, Proc. Natl. Acad. Sci. USA, 67, 225-232.
Ayala, F. J,. & Tracey, M. L. (1974). Genetic differentiation within and between species of the Drosophila willistoni group, Proc. Natl. Acad. Sci. USA, 71, 999-1003.
Ayala, F. J., Tracey, M .L., Hedgecock, D., & Richmond, R. C. (1974). Genetic differentiation during the speciation process in Drosophila, Evolution, 28, 576-592.
Ayala, F. J., Barrio, E., & Kwiatowski, J. (1996). Molecular clock or erratic evolution? A tale of two genes, Proc. Natl. Acad. Sci. USA, 93, 11729-11734
Ayala, F. J., & Cela-Conde, C. J. (2017). Processes in Human Evolution. The journey from early hominins to Neanderthals and modern humans. Oxford University Press.
Bateson W. (1909). Mendel’s principle of heredity. Cambridge University Press.
Benton, M. J., & Ayala, F. J. (2003). Dating the Tree of Life, Science, 300, 1698-1700.
Cela-Conde, C J., & Ayala, F. J. (2017a). The Advent of Biological Evolution and Humankind: Chance or Necessity?, In: M. Tibayrenc and F.J. Ayala (eds.). On Human Nature. Biology, Psychology, Ethics, Politics, and Religion (pp. 3-15). Academic Press.
Cela-Conde, C.J., & Ayala, F. J. (2017b). Science and Technology in Human Societies: From Tool Making to Technology. In: M. Tibayrenc and F.J. Ayala (eds.). On Human Nature. Biology, Psychology, Ethics, Politics, and Religion (pp. 729-755). Academic Press.
Crow, J. F., & Kimura, M. (1970). An introduction to population genetics theory. Blackburn Press.
Dobzhansky, Th. (1970). Genetics of the Evolutionary Process. Columbia University Press.
Escalante, A. A., & Ayala, F. J. (1994). Phylogeny of the malarial genus Plasmodium, derived from rRNA gene sequences, Proc. Natl. Acad. Sci. USA, 91, 11373-11377.
Escalante, A. A., Lal, A. A., & Ayala, F. J. (1998). Genetic Polymorphism and Natural Selection in the Malaria Parasite Plasmodium falciparum, Genetics, 149, 189-202.
Felsenstein, (1971). On the biological significance of the cost of a gene substitution, Amer. Natur., 105, 1-11.
Fisher, R. A. (1918). The Correlation between Relatives on the Supposition of Mendelian Inheritance, Transactions of the Royal Society of Edinburgh, 53, 399-433.
Fisher, R. A. (1930). The Genetical Theory of Natural Selection, Clarendon Press.
Ford E. B. (1965). Genetic polymorphism, MIT Press.
Gaut, B. S., Muse, S. V., Clark, W. D., & Clegg, M. T. (1992). Relative rates of nucleotide substitution at the rbcL locus in monocotyledonous plants, J. Molec. Evol., 35, 292-303.
Haldane, J. B. S. (1932). The Causes of Evolution, Longmans, Green & Co.
Haldane, J. B. S. (1949). Disease and evolution. Ricerca Science Supplement, 19, 3–10.
Harris, H. (1966). Enzyme polymorphisms in man. Proc. Roy. Soc. Ser.B., 164, 298-310.
Hu, W., Hao, Z., Du, P., Vincenzo, F. D., Anzi G., Cui, J., Fu, Y-X., Pan, Y-H., & Li, H. (2023). Genomic inference of a severe human bottleneck during the Early to Middle Pleistocene transition, Science, 381, 979-984.
Hunter, R. L., & Markert, C. L. (1957). Histochemical demonstration of enzymes separated by zone electrophoresis in starch gels, Science, 125 (3261), 1294–1295.
Kimura, M. (1968). Evolutionary rate at the molecular level, Nature, 217 (5129), 624–626.
Kimura, M., & Ohta, T. (1971). Theoretical Aspects of Population Genetics. Princeton University Press.
Lewontin, R.C. (1974). Genetic Basis of Evolutionary Change. Colombia University Press.
Muller, H. J. (1950). Our load of mutations, Am. J. Hum. Genet., 2, 111-76.
Ohta, T. (1971). Associative overdominance caused by linked detrimental mutations, Genet. Res., 18, 277–286.
Popper, K. (1959). The logic of Scientific Discovery. The logic of scientific discovery. Central Works of Philosophy v4: Twentieth Century.
Provine, W. B. (1971). The Origins of Theoretical Population Genetics. University of Chicago Press.
Richter, D., Grün, R., Joannes-Boyau, R., Steele, T. E., Amani, F., Rué, M., Fernandes, P., Raynal, J.-P., Geraads, D., Ben-Ncer, A., Hublin, J.-J., & McPherron, S. P. (2017). The age of the hominin fossils from Jebel Irhoud, Morocco, and the origins of the Middle Stone Age, Nature, 546 (7657), 293-296.
Ritland, K., & Clegg, M. T. (1987). Evolutionary analysis of plant DNA sequences, Amer. Natur., 130, S74-S100.
Rodriguez-Trelles, F., Tarrio, R., & Ayala, F. J. (2001). Erratic overdispersion of three molecular clocks: GPDH, SOD, and XDH, Proc. Natl. Acad. Sci. USA, 98, 11405-11410.
Schrödinger, E. (1944). What is life? Cambridge Univ Press.
Seddon, C. (2022). Humans from the Beginning. Glanville Publications.
Sriram, S., Mallick, S., Patterson, N., & Reich, D. (2016). The combined landscape of Denisovan and Neanderthal ancestry in present-day humans, PLOS Genet., 26, 1241-1247.
Tibayrenc, M., & Ayala, F. J. (2000). Molecular epidemiology and evolutionary genetics of pathogenic microorganisms: analysis and interpretation of data, In: R.C.A. Thompson, (ed.). Molecular Epidemiology of Infectious Diseases (pp. 20- 29). Arnold.
Wright, S. (1931). Evolution in Mendelian Populations, Genetics, 16, 97-159.
Zuckerkandl E., & Pauling, L. (1966). Evolutionary Divergence and Convergence in Proteins, In V. Bryson, H. Vogel (eds.). Evolving Genes and Proteins (pp. 97-166). Academic Press.
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